Integrative Biomedical Research
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Integrative Biomedical Research
Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles on all aspects of biomedical, medicine, public health,
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Integrative Biomedical Research
Volume 9 Number 1 2025
Table of Contents
Research Article
Metabolism and Biochemistry
Bandr Fakiha 1*
This study emphasizes the need for preventive measures, caregiver education, and improved healthcare systems to reduce pediatric poisoning incidents.
Abstract | Full Text |PDF (288 KB) | Open Access Article
Toxicological Assessment of Azo Dye Brown HT In Vivo
T M Tawabul Islam1, Nirmal Chandra Mahat2, Ivvala Anand Shaker3, Abul Kashem Tang2, Sheikh Arafat Rahman2, Mustakin Ahmed Shohel1, Inampudi Sailaja4*
This study demonstrated the adverse effects of azo dye Brown HT on juvenile health, underscoring the need for safer food practices to protect vulnerable populations.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Tissue Factor Levels Used as Coagulation Biomarkers in Diabetic and Hypertensive Patients
Waleed Haji Saeed 1*, Zikri Mahmood Mirza 1, Mohammed Rashid Ameen 1, Sarkaft Ghareeb Omer 2
This study dtermined elevated Tissue Factor levels as a potential biomarker for thrombotic risk in diabetic and hypertensive patients.
Abstract | Full Text |PDF (221 KB) | Open Access Article
Chronic Toxic Effects of Chocolate Brown HT Dye on Hepatorenal Functions In Vivo
T M Tawabul Islam 1, Abul Kashem Tang 2, Inampudi Sailaja 3, Mustakin Ahmed Shohel 1, Sheikh Arafat Rahman 2, Nirmal Chandra Mahat 2, Ivvala Anand Shaker 4*
This study showed the gender-specific toxicological impacts of Chocolate Brown HT as safer food colorant practices and regulatory guidelines.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Natural Diabetes Treatment with Litchi Seeds Extract In Vivo
Mustakin Ahmed Shohel 1, Abul Kashem Tang 2, Inampudi Sailaja 3, T M Tawabul Islam 1, Md. Humayan Kabir 2, Nirmal Chandra Mahat 2, Ivvala Anand Shaker 4*
This study demonstrated the therapeutic potential of litchi seeds for diabetes as safer, effective alternatives to synthetic drugs.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Fouad Ziedan Hamza Al-Quraishi 1*, Bassam Abdulameer Mohammed Al-Madany 1*, Mohammed Abdaljaleel 1, Fadhel Al-Kraawi 1, Zainab Mohammed Kadhim Hirzuldeen 1, Karrar Talib Salman Al-Ibrahimi 1
The study showed fenugreek’s potential to improve male fertility by enhancing sperm characteristics in hypothyroid conditions.
Abstract | Full Text |PDF (225 KB) | Open Access Article
Osama Abdel-Hameed Majeed 1*, Makarim Qassim Al-Lami 1, Gheyath AlGawwam 2
This study showed the biochemical and immunological links between Parkinson's Disease and gastrointestinal disorders, highlighting shared pathophysiological markers.
Abstract | Full Text |PDF (420 KB) | Open Access Article
Fenugreek Induces The Sperm Characteristics in Hypothyroid Male Rats
Fouad Ziedan Hamza Al-Quraishi 1*, Bassam Abdulameer Mohammed Al-Madany 1*, Mohammed Abdaljaleel Fadhel Al-Kraawi 1, Zainab Mohammed Kadhim Hirzuldeen 1, Karrar Talib Salman Al-Ibrahimi 1
This study demonstrated fenugreek's potential to improve sperm quality and hormone levels in hypothyroid male rats, suggesting therapeutic benefits.
Abstract | Full Text |PDF (270 KB) | Open Access Article
Diagnostic Efficacy of Tumor Markers AFP, CA19-9, and CEA in Hepatocellular Carcinoma Patients
Tufael 1*, Auditi Kar 2, Md Haroon Or Rashid 3, Atiqur Rahman Sunny 4*, António Raposo 5, Md. Saidul Islam 6, Md. Anower Hussain 7, Mohammad Anowar Hussen 8, Heesup Han 9, Henrique Douglas Melo Coutinho 10, Md. Sefaut Ullah 11, Md. Mizanur Rahman12
Early detection of hepatocellular carcinoma (HCC) is vital for improving patient outcomes. Chemiluminescence assays showed enhanced diagnostic accuracy, providing timely intervention and treatment.
Abstract | Full Text |PDF (418 KB) | Open Access Article
Lymphocyte, IL-10, IL-6, and IFN-g Cytokines Modulation in SARS-CoV-2 Patients
Inaam Ali Abid 1*, Ismail Ibrahim Latif 2, Namer Fadhil Ghaab 3, Saad Ahmed Ali Jadoo 4
The study showed gender disparities in COVID-19 severity, revealing elevated cytokine levels of IL-10, IL-6, and IFN-g in males, as a potential immune response variations.
Abstract | Full Text |PDF (308 KB) | Open Access Article
Khamees M. Al-Dulaimy 1, Zaynab Hameed Ibrahim 1, Bassim Mohammed Salman 1*
Understanding the genetic basis of cystinosis aids in early diagnosis, genetic counseling, and potential gene therapy approaches for disease management.
Abstract | Full Text |PDF (271 KB) | Open Access Article
Nutritional Evaluation of Cassava Meal Components and Maize in Securing Feed and Food
Shahabuddin Ahmed1,2, Mrityunjoy Biswas2*, Atiqur Rahman Sunny3, Farhana Irin4, Md Faruk Hossain5, Md Mostafizur Rahman5, Md Abu Bakar Siddique5, Md. Alauddin 6, Mrinal Kanti Debnath2, Md. Pallo Hossain2, Tufael3, 7
This study determined the nutritional composition of cassava and maize, pivotal crops for food and animal feed production globally, offering insights into dietary recommendations, agricultural practices, and food security measures in regions reliant on these staples.
Abstract | Full Text |PDF (305 KB) | Open Access Article
Tufael 1, Auditi Kar 2, Vijay Jagdish Upadhye 3*, Amith Dutta 4, Md Royhanur Islam 5, Abdus Sattar 6, Md. Eunus Ali 7, Julakha Akter 8, Kaniz Fatima Bari 9, Md. Tahsin Salam 10, Palash Chandra Banik 11, Md Shamsuddin Sultan Khan 12, Atiqur Rahman Sunny 6*
The research addresses a crucial gap by linking the unique lifestyle and stressors in fisher groups to hepatocellular carcinoma.
Abstract | Full Text |PDF (410 KB) | Open Access Article
Mohamed Sadeq Al-Ibrahim *1, Ahmad Hamdy Ibrahim 2, Sawsan S. Al- Rawi *3, Bayram Dawod Ahmed 4, Nalan Linda Fraim 5
Chronic stress affects many physiological processes including immunity and angiogenesis. IBS impacts anxiety, quality of life, and academic performance of undergraduate students.
Abstract | Full Text |PDF (305 KB) | Open Access Article
Reviews
Metabolism and Biochemistry
Analysis of Potential Biomarkers in Hypertension
Alexander V. Blagov1*, Margarita A. Sazonova 1,2, Anastasia I. Ryzhkova1, Marina D. Sazonova1, Mikhail A. Popov6, Egor Yu. Budnikov1, Paolo Poggio7, Donato Moschetta7, Yuri V. Arkhipenko1,3, Vasily P. Karagodin5, Alexander N. Orekhov1,4
Biomarker-driven hypertension diagnostics enhance early detection, predict complications, and support precision medicine strategies to reduce global cardiovascular disease burden.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Two Sides of Triglycerides in Atherogenesis: An Essential Contributor
Anastasia V. Poznyak 1*, Tatyana Vladimirovna Kirichenko 2,5, Tatiana Ivanovna Kovyanova 1,2, Irina Alexandrovna Starodubtseva 3, Dmitry Felixovich Beloyartsev 4, Vasily N. Sukhorukov 2, Alexander N. Orekhov 2
This review discusses the role of triglycerides in atherogenesis and their potential as biomarkers in cardiovascular disease development.
Abstract | Full Text |PDF (388 KB) | Open Access Article
The Strength in Breakdown: Understanding Mitophagy and Its Implications in Cardiovascular Diseases
Anastasia V. Poznyak 1*, Alexey V. Churov 2,3, Natalia V. Elizova 2, Tatiana Ivanovna Kovyanova 1,2, Vasily N. Sukhorukov 3,4, Alexander N. Orekhov 3,4*
Understanding mitophagy's role in cardiovascular health offers potential therapeutic insights for related disorders.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Ancient DNA: Cardiovascular Disease Prediction from Mummies
Anastasia V. Poznyak 1*, Tatyana Vladimirovna Kirichenko 2,5, Natalia V. Elizova 2, Alexey V. Churov 2,6, Tatiana Ivanovna Kovyanova 1,2, Irina Alexandrovna Starodubtseva 3, Vasily N. Sukhorukov 2,5, and Alexander N. Orekhov 2,5
Understanding CVD's genetic roots through ancient mummies reveals its historical prevalence and informs contemporary health.
Abstract | Full Text |PDF (201 KB) | Open Access Article
Iza Safany Che Hanafi 1, Chandrarohini Saravanan 2, Rabiatul Basria S. M. N. Mydin 2*
This review discusses how oxidative stress affects our bodies due to factors like diet, stress, and environment, and how antioxidants help. Understanding this is crucial for fighting diseases like cancer and staying healthy.
Abstract | Full Text |PDF (219 KB) | Open Access Article
Repurposing Drugs for Overcoming Therapy Resistance in Colon Cancer – A Review
Mahdi Darvishi 1, Amir Mohammad Chekeni 2, Mohammad Fazelhosseini 1, Zeenat Iqbal 3*, Mohd Aamir Mirza 3*, Mohammed Aslam 4, Esra Tariq Anwer Bayrakdar 4
Oncology research seeks new therapies for aggressive CRC, utilizing repurposed drugs for accelerated and safer treatment approaches.
Abstract | Full Text |PDF (842 KB) | Open Access Article
The peer-reviewed and edited version of record published online before inclusion in an issue
These articles have been peer reviewed and accepted for publication. They are still in production and have not been edited, so may differ from the final published form.
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Advanced Dissolution Testing for Novel Drug Formulations: Challenges, Emerging Methods, and Regulatory Perspectives
This study enhances drug release evaluation and improves therapeutic outcomes using advanced dissolution testing techniques.
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Analysis of Potential Biomarkers in Hypertension
Biomarker-driven hypertension diagnostics enhance early detection, predict complications, and support precision medicine strategies to reduce global cardiovascular disease burden.
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Predicting Habitat Suitability and Climate Change Impact on Medicinal plant Dalbergia latifolia and Dillenia pentagyna Using Ecological Niche Modelling
This study models current and future habitats, highlighting climate-driven distribution shifts and guiding conservation strategies for two economically valuable medicinal plants.
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A Comparative Analysis of Bioavailability and Stability of Anti-Diabetic Drugs in Conventional vs. Nanoparticle-Based Formulations – A Review
The study underscores nanoparticles' potential to improve stability, bioavailability, and therapeutic efficacy of anti-diabetic drugs versus conventional formulations.
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Effects of Physical Activity as A Treatment For Depression in the Elderly
Identifying effective physical activities for elderly depression supports holistic, low-cost, evidence-based interventions that enhance mental health and healthy aging.
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Strategic Impurity Control in Next-Generation Pharmaceuticals: Analytical Technologies, Toxicological Assessment, and Regulatory Integration
Effective impurity control safeguards patient safety while accelerating pharmaceutical innovation and regulatory approval.
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Collaborative Governance in Combating Illegal Cosmetics: A Study of Multi-Stakeholder Dynamics in South Sulawesi, Indonesia
This study evaluates collaborative governance in South Sulawesi to address illegal cosmetics, enhancing public health, regulatory compliance, and stakeholder coordination.
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Smart Nutrition and Active Living in Hypertension Management: Assessing Lifestyle Behaviors, Barriers, and the Role of Digital Health Tools
This study is significant as it highlights the effectiveness of smart nutrition and active living in managing hypertension, promoting sustainable, non-pharmacological interventions for better cardiovascular health.
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High Viral Load is a Risk Factor for Hepatocellular Carcinoma: Clinical and Laboratory Insights from a Cross-Sectional Study
High viral load in HCC patients correlates with worsened liver function, systemic complications, and increased mortality, underscoring the need for early intervention.
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Cardiovascular Complications in Patients with Hepatocellular Carcinoma
The study seeks to develop an HCC risk profile framework for clinicians to identify patients who may be at risk.
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The Importance of Autoimmunity and Chronic Inflammation in the Development of Atherosclerosis: New Treatment Strategies
Understanding immune mechanisms in atherosclerosis enables development of targeted anti-inflammatory therapies, improving cardiovascular outcomes and plaque stabilization strategies.
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Multidisciplinary Challenges in Managing a Ruptured Ascending Aortic Aneurysm with Concurrent Pulmonary Pathology: A Case Report
This case highlights the challenges of managing ruptured aortic aneurysms with comorbidities, emphasizing multidisciplinary care and TEVAR’s limitations in complex cases.
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The Evolving Role of Hospital and Community Pharmacist in Post-COVID-19 Healthcare Delivery in Bangladesh: A Survey-Based Analysis
This study highlights post-pandemic roles of Bangladeshi pharmacists, emphasizing their evolving contributions to healthcare access, management, and therapeutic decision-making.
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AI-driven Innovations in Cancer Research and Personalized Healthcare
This study demonstrated the potential of AI to revolutionize cancer care through improved diagnostics, personalized treatment, and ethical implementation.
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Synthesis, Characterization, and Antioxidant Potential of Nickel (II) Phthalocyanine for Industrial and Biomedical Applications
This study determined Nickel (II) phthalocyanine's antioxidant efficacy, structural characterization, and versatile applications in industry and therapeutic advancements.
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Bacteriological Profile of Bacteremia and Antibiotic Resistance Patterns of the Isolated Pathogens
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Antidiabetic and Toxicological Evaluation of Ostodes Pauciflora merr. Seed (kop nut) Oil, A Potential Functional Food Alternative
This study evaluates Ostodes pauciflora Merr. seed oil for antidiabetic properties, providing insights into its potential as a functional food alternative.
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An Insight into the Role of Artificial Intelligence in the Early Diagnosis of Alzheimer’s Disease
AI improves diagnosis, treatment planning, and patient outcomes by enabling early, accurate Alzheimer's disease identification using sophisticated data analysis.
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Cardiometabolic Impact of Vitamin D Deficiency as a Determinant of Coronary Artery Disease: A Review
The results demonstrate a strong link between vitamin D deficiency and an increased risk of coronary heart disease in adults.
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Potential Therapeutic Targets Associated with the Autoimmune Response in Crohn's Disease
This review elucidates autoimmune mechanisms in Crohn’s disease, highlighting emerging molecular targets to advance precision immunotherapy and improve patient outcomes.
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Deep Mapping of Neuro-phenotypes Using AI-Enhanced MRI: A Contrast-Based Multiplanar Analysis
AI-driven contrast mapping enhances voxel-level T2-MRI brain analysis, revealing phenotypic variations crucial for early diagnosis and neurodevelopmental profiling
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Revolutionizing Healthcare: The Role of Artificial Intelligence in Drug Discovery and Delivery
This study shows how AI can change the way drugs are made and delivered, making healthcare faster, more personalized, and cheaper.
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TGF-β1 as a Molecular Target and Vitamin D Interaction in Diabetic Nephropathy: A Bio-clinical Correlation Study
Clarifies the potential role of vitamin D and kidney dysfunction in diabetic nephropathy through clinical and molecular analysis.
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Integrating Molecular Modeling and Kinetic Insights to Decipher Structure–Activity Relationship Trends in Small-Molecule Inhibitors of α-Glycosidases
This study clarifies structural features driving potent α-glycosidase inhibition, enabling rational design of selective therapeutics through integrated computational–experimental mechanistic insights.
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Multichemical Endocrine Disruption of Thyroid and Sex Hormone Signaling Drives Early-Life Neurodevelopmental Impairments
This study highlights how prenatal endocrine disruptor exposure impairs neurodevelopment, emphasizing mixture effects, biological mechanisms, and urgent regulatory intervention needs.