Integrative Biomedical Research
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Integrative Biomedical Research
Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles on all aspects of biomedical, medicine, public health,
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Integrative Biomedical Research
Volume 9 Number 1 2025
Table of Contents
Research Article
Chemistry
Mohammed Abbas Al-Silaykhee1 , Saif Ddin Kadhoum Al-Zamili2 , Ahmed Ghdhban Al-Ziaydi1*
This study determined Nickel (II) phthalocyanine's antioxidant efficacy, structural characterization, and versatile applications in industry and therapeutic advancements.
Abstract | Full Text |PDF (519 KB) | Open Access Article
Damilola A. Omoboyowa1*, Elijah A. Agboola 1, Damilola S. Bodun 1, Simbo T. Akinsulure 1, Samia Belahcene 2, Dhurgham Al-Fahad 3
Curculigo pilosa extracts exhibit strong antioxidant properties, mitigating oxidative stress in Drosophila melanogaster, highlighting potential therapeutic applications.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Synergistic Effects of Cinnamomum zeylanicum and Atorvastatin in streptozotocin-Induced In Vivo
Sakina Ruhi1, Nur Alyssya Binti Yusoff 2*, Sohayla M. Attalla3, Jiyauddin Khan3, Norshafarina Shari Kamaruddin3, Indang Ariati2, Husni Ahmed Al-Gosha1, Subramanian Rammohan1, Ayesha Syed 1, Rajesh Thangarajan1
This study assesses the combined effects of Cinnamomum zeylanicum and atorvastatin on glucose regulation, lipid metabolism, and organ function in diabetic models.
Abstract | Full Text |PDF (220 KB) | Open Access Article
Hala Salim Sonbol 1*, Alaa Muqbil Al-sirhani 2
This study showed understanding of PC1's GPS domain, crucial for ADPKD, through successful expression and purification using MBP fusion.
Abstract | Full Text |PDF (854 KB) | Open Access Article
Ameliorative Effect of Red Grape Leaf Extract on Insulin Resistance: In Vivo And In Silico Studies
Naglaa M. Hamdy 1, 2*, Hanan M. El-Tantawy 1
Red grape leaf extract contains polyphenols, particularly resveratrol, which can potentially control insulin resistance and non-alcoholic fatty liver disease.
Abstract | Full Text |PDF (690 KB) | Open Access Article
Immune Response Dynamics and Chemokine Profile from MCP-1 and MIP-1α in Toxoplasma gondii Infection
Nawras Alwan Hussain Ali 1, Saleem Khteer Al-Hadraawy 1*
This study determined the MCP-1 and MIP-1α Dynamics in Toxoplasma Infection as an implications for Immune Response and Biomarkers
Abstract | Full Text |PDF (294 KB) | Open Access Article
A Study of Biochemical Markers in Uterine Cancer Diagnosis with Radiotherpay Treatment In Iraq
Wael Sahib Alnweny 1*, Mohammed Q. Almayali 1*, Mohammed A. Dakhil 2, Hiba Ali Numan 1, Yasir J. Abbas 3
Effect and investigation of radiotherapy of clinical biomarkers in Uterine Cancer patients.
Abstract | Full Text |PDF (266 KB) | Open Access Article
S. Maria Sylviaa 1*, N. Sudha 1
Early Breast Cancer diagnosis via data mining is crucial. Proposed methods achieve high accuracy, improving treatment outcomes for patients significantly.
Abstract | Full Text |PDF (852 KB) | Open Access Article
Huda Azhar Fadel 1*, Lekaa Hussein Khdaim 1
Iraqi date core-derived activated carbon effectively removes acetamiprid pesticide, crucial for combating water pollution, supported by comprehensive adsorption studies.
Abstract | Full Text |PDF (551 KB) | Open Access Article
Mukhlif Mohsin Slaihim 1*, Luay Ali Dhahi 1, Abeer Hussein Ali 1
Introduced piperidine-catalyzed protection in aldehydes, guiding anti-cancer compound optimization.
Abstract | Full Text |PDF (804 KB) |Supplementary Material | Open Access Article
Reviews
Chemistry
Fahimeh Feili1,2, Mohamad Ali Roozegar 1,2*, Aminollah Vasigh3
This study determined the high prevalence of musculoskeletal disorders among dental students in Iran, urging the need for preventive ergonomic interventions.
Abstract | Full Text |PDF (176 KB) | Open Access Article
Mohd. Javed Naim 1*
This review highlights the therapeutic potential of quinazoline derivatives in cancer treatment, focusing on their ability to target critical tyrosine kinases and offering insights into their development as effective anticancer agents.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Advances in SGLT2 Inhibitors for Type 2 Diabetes Management
Mohd. Javed Naim 1*
This review highlights novel SGLT2 inhibitors, emphasizing their potential in enhancing therapeutic options for type 2 diabetes management.
Abstract | Full Text |PDF (933 KB) | Open Access Article
Wahyu Widodo 1*, Faridah Binti Mohd Said 2, Musheer 2
Evaluating mobile Health Belief Model applications can enhance diabetes care by improving patient knowledge, adherence, and preventing complications.
Abstract | Full Text |PDF (162 KB) | Open Access Article
Mugihartadi 1*, Faridah Binti Mohd Said 2, Nisha Nambiar 2
Logotherapy might improve quality of life in CKD patients, emphasizing psychological support as an integral component of holistic care.
Abstract | Full Text |PDF (373 KB) | Open Access Article
Wahidin 1,2*, Faridah Mohd Said 2, Musheer Abdulwahid Aljaberi 2
This review discusses the effectiveness of ACT and therapeutic relationships in reducing PTSD symptoms among surgical patients postoperatively.
Abstract | Full Text |PDF (150 KB) | Open Access Article
The Clinical, Histological, and Immunohistochemical Features of Bone Metastases - A Review
Ragini Patel 1*, Yogendra Sahu 2
A deep learning model to trace bone metastasis origins, addressing challenges in diagnosis and emphasizing therapeutic implications and monitoring.
Abstract | Full Text |PDF (698 KB) | Open Access Article
The peer-reviewed and edited version of record published online before inclusion in an issue
These articles have been peer reviewed and accepted for publication. They are still in production and have not been edited, so may differ from the final published form.
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Advanced Dissolution Testing for Novel Drug Formulations: Challenges, Emerging Methods, and Regulatory Perspectives
This study enhances drug release evaluation and improves therapeutic outcomes using advanced dissolution testing techniques.
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Analysis of Potential Biomarkers in Hypertension
Biomarker-driven hypertension diagnostics enhance early detection, predict complications, and support precision medicine strategies to reduce global cardiovascular disease burden.
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Predicting Habitat Suitability and Climate Change Impact on Medicinal plant Dalbergia latifolia and Dillenia pentagyna Using Ecological Niche Modelling
This study models current and future habitats, highlighting climate-driven distribution shifts and guiding conservation strategies for two economically valuable medicinal plants.
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A Comparative Analysis of Bioavailability and Stability of Anti-Diabetic Drugs in Conventional vs. Nanoparticle-Based Formulations – A Review
The study underscores nanoparticles' potential to improve stability, bioavailability, and therapeutic efficacy of anti-diabetic drugs versus conventional formulations.
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Effects of Physical Activity as A Treatment For Depression in the Elderly
Identifying effective physical activities for elderly depression supports holistic, low-cost, evidence-based interventions that enhance mental health and healthy aging.
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Strategic Impurity Control in Next-Generation Pharmaceuticals: Analytical Technologies, Toxicological Assessment, and Regulatory Integration
Effective impurity control safeguards patient safety while accelerating pharmaceutical innovation and regulatory approval.
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Collaborative Governance in Combating Illegal Cosmetics: A Study of Multi-Stakeholder Dynamics in South Sulawesi, Indonesia
This study evaluates collaborative governance in South Sulawesi to address illegal cosmetics, enhancing public health, regulatory compliance, and stakeholder coordination.
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Smart Nutrition and Active Living in Hypertension Management: Assessing Lifestyle Behaviors, Barriers, and the Role of Digital Health Tools
This study is significant as it highlights the effectiveness of smart nutrition and active living in managing hypertension, promoting sustainable, non-pharmacological interventions for better cardiovascular health.
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High Viral Load is a Risk Factor for Hepatocellular Carcinoma: Clinical and Laboratory Insights from a Cross-Sectional Study
High viral load in HCC patients correlates with worsened liver function, systemic complications, and increased mortality, underscoring the need for early intervention.
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Cardiovascular Complications in Patients with Hepatocellular Carcinoma
The study seeks to develop an HCC risk profile framework for clinicians to identify patients who may be at risk.
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The Importance of Autoimmunity and Chronic Inflammation in the Development of Atherosclerosis: New Treatment Strategies
Understanding immune mechanisms in atherosclerosis enables development of targeted anti-inflammatory therapies, improving cardiovascular outcomes and plaque stabilization strategies.
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Multidisciplinary Challenges in Managing a Ruptured Ascending Aortic Aneurysm with Concurrent Pulmonary Pathology: A Case Report
This case highlights the challenges of managing ruptured aortic aneurysms with comorbidities, emphasizing multidisciplinary care and TEVAR’s limitations in complex cases.
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The Evolving Role of Hospital and Community Pharmacist in Post-COVID-19 Healthcare Delivery in Bangladesh: A Survey-Based Analysis
This study highlights post-pandemic roles of Bangladeshi pharmacists, emphasizing their evolving contributions to healthcare access, management, and therapeutic decision-making.
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AI-driven Innovations in Cancer Research and Personalized Healthcare
This study demonstrated the potential of AI to revolutionize cancer care through improved diagnostics, personalized treatment, and ethical implementation.
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Synthesis, Characterization, and Antioxidant Potential of Nickel (II) Phthalocyanine for Industrial and Biomedical Applications
This study determined Nickel (II) phthalocyanine's antioxidant efficacy, structural characterization, and versatile applications in industry and therapeutic advancements.
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Bacteriological Profile of Bacteremia and Antibiotic Resistance Patterns of the Isolated Pathogens
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Antidiabetic and Toxicological Evaluation of Ostodes Pauciflora merr. Seed (kop nut) Oil, A Potential Functional Food Alternative
This study evaluates Ostodes pauciflora Merr. seed oil for antidiabetic properties, providing insights into its potential as a functional food alternative.
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An Insight into the Role of Artificial Intelligence in the Early Diagnosis of Alzheimer’s Disease
AI improves diagnosis, treatment planning, and patient outcomes by enabling early, accurate Alzheimer's disease identification using sophisticated data analysis.
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Cardiometabolic Impact of Vitamin D Deficiency as a Determinant of Coronary Artery Disease: A Review
The results demonstrate a strong link between vitamin D deficiency and an increased risk of coronary heart disease in adults.
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Potential Therapeutic Targets Associated with the Autoimmune Response in Crohn's Disease
This review elucidates autoimmune mechanisms in Crohn’s disease, highlighting emerging molecular targets to advance precision immunotherapy and improve patient outcomes.
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Deep Mapping of Neuro-phenotypes Using AI-Enhanced MRI: A Contrast-Based Multiplanar Analysis
AI-driven contrast mapping enhances voxel-level T2-MRI brain analysis, revealing phenotypic variations crucial for early diagnosis and neurodevelopmental profiling
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Revolutionizing Healthcare: The Role of Artificial Intelligence in Drug Discovery and Delivery
This study shows how AI can change the way drugs are made and delivered, making healthcare faster, more personalized, and cheaper.
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TGF-β1 as a Molecular Target and Vitamin D Interaction in Diabetic Nephropathy: A Bio-clinical Correlation Study
Clarifies the potential role of vitamin D and kidney dysfunction in diabetic nephropathy through clinical and molecular analysis.
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Integrating Molecular Modeling and Kinetic Insights to Decipher Structure–Activity Relationship Trends in Small-Molecule Inhibitors of α-Glycosidases
This study clarifies structural features driving potent α-glycosidase inhibition, enabling rational design of selective therapeutics through integrated computational–experimental mechanistic insights.
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Multichemical Endocrine Disruption of Thyroid and Sex Hormone Signaling Drives Early-Life Neurodevelopmental Impairments
This study highlights how prenatal endocrine disruptor exposure impairs neurodevelopment, emphasizing mixture effects, biological mechanisms, and urgent regulatory intervention needs.