Integrative Biomedical Research
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Integrative Biomedical Research
Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles on all aspects of biomedical, medicine, public health,
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Integrative Biomedical Research
Volume 9 Number 1 2025
Table of Contents
Case Study
Cell and Developmental Biology
Daud Yudhistira Sukanto 1, Danang Himawan Limanto 1*
This case highlights the challenges of managing ruptured aortic aneurysms with comorbidities, emphasizing multidisciplinary care and TEVAR’s limitations in complex cases.
Abstract | Full Text |PDF (796 KB) | Open Access Article
Research Article
Cell and Developmental Biology
Zulfayandi Pawanis1, Heroe Soebroto2, Dhihintia Jiwangga2, Yan Efrata Sembiring, Puruhito2
SDS significantly reduces type I and III collagen density in decellularized bovine pericardium, whereas H2O2 better preserves extracellular matrix integrity.
Abstract | Full Text |PDF (344 KB) | Open Access Article
Nanotechnology-Enhanced Chemoradiotherapy Using Copper and Gold Nanoparticles for Esophageal Cancer
Keyan Zang1*
Nanotechnology might induce esophageal cancer treatment, enhancing patient outcomes with copper and gold nanoparticles boosting therapy efficacy and diagnostic precision.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Shler Ali Khorsheed 1*
Accurate diagnosis of Helicobacter pylori infection is crucial due to its association with gastrointestinal diseases, including ulcers and cancer.
Abstract | Full Text |PDF (237 KB) | Open Access Article
Ahmed Saadi Mohammed 1*, Hiwa Abubakr Hussein 2, Saad Ahmed Ali Jadoo 3, Mohanned H. Alsalaumy 4, Laith Falah Hassan 5, Muhammad Rasul Hussein 6
Early diagnosis of chronic liver disease is vital for intervention. Transient elastography aids in predicting fibrosis, guiding treatment decisions effectively.
Abstract | Full Text |PDF (316 KB) | Open Access Article
Zahraa Redha Shamsee 1*, Aida Hussain Ibrahim 1
Klebsiella pneumoniae shows a global threat due to its multidrug resistance. This study elucidated resistance mechanisms and antibiotic susceptibility, crucial for treatment strategies.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Ahmed Jassim Muklive Al-Ogaidi 1*, Hamssa Ahmed Easa 1, Shaymaa S. Hassan 1, Firas Al-Oqaili 1, Liblab S. Jassim 1
Spectrophotometric evaluation of sulphonamide using azo compounds offers a rapid, sensitive, and cost-effective method for quantitative pharmaceutical analysis.
Abstract | Full Text |PDF (506 KB) | Open Access Article
Rusul Hazim Al-darajee 1*, Masarat S. Al-Mayahi 1
The study on goat uterine morphology and histology offers insights into reproductive health and breeding management for sustainable agriculture.
Abstract | Full Text |PDF (2 MB) | Open Access Article
Study of Antibiotic Resistance in ESKAPE Bacteria Using β-lactamase and ESBL Genes
Hiba Ahmed Jawade 1*, Zahraa Yosif Motaweq 2, Hawraa Dheyaa Rasool 3, Fatima Hassan Hussain 1
This study determined the resistance mechanisms of SKAPE group bacteria. Understanding this bacterial resistance mechanisms, particularly β-lactamase production, is crucial for effective treatment and infection control.
Abstract | Full Text |PDF (800 KB) | Open Access Article
Effects of Slow Deep Breathing Exercises in Patients with Coronary Artery Disease
Zahra Abdulmunem Ahmed 1*, Hussam Abbas Dawood 2*
In this A Quasi-Experimental Study, we have shown enhanced effect Cardiovascular Health in Coronary Artery Disease Patients Through Deep Breathing Exercises with Incentive Spirometry.
Abstract | Full Text |PDF (266 KB) | Open Access Article
Synthesis, Characterization and Antibacterial Evaluation of Novel Thiazolidine Derivatives
Shaima H. Abdullah 1*, Mahmoud M. Salih 1, Khalid, A. Al-Badrany 1*
Thiazolidine derivatives, synthesized from heterocyclic compounds, exhibit diverse biological activities, including antibacterial effects against various bacterial strains, suggesting potential pharmaceutical applications.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Spectrophotometric Determination of Vitamin C Using Indirect Oxidation with a New Organic Dye
Asmaa Ahmed Mohammed Alrashidy 1, Omar Adnan Hashem 1, Kalid Abdul-Aziz ALBadrany 1
The research focuses on the indirect determination of vitamin C in various pharmaceutical formulations, as well as in natural fruit samples and commercially available juices. For the first time, a novel organic dye was utilized in the process, and it was found that the method was indeed effective for the quantification of vitamin C in these products.
Abstract | Full Text |PDF (448 KB) | Open Access Article
Mohammed Qassim Baktash 1* , Ali Ismael Sulaiman 1
Understanding hypertension in Telafer City adults is vital for preventing problems, guiding interventions, and managing the disease effectively
Abstract | Full Text |PDF (294 KB) | Open Access Article
Reviews
Cell and Developmental Biology
Alexander V. Blagov1*, Vladislav A. Kalmykov1, Olga N. Maltseva2, Alikhan Z. Asoyan1, Anastasia O. Maksaeva1,3, Alexander N. Orekhov1,4*
Understanding immune mechanisms in atherosclerosis enables development of targeted anti-inflammatory therapies, improving cardiovascular outcomes and plaque stabilization strategies.
Abstract | Full Text |PDF (239 KB) | Open Access Article
Microbial Avengers: How Microorganisms Drive Angiogenesis for Good and Bad?
Md. Fakruddin1*, Zarifah Chowdhury1, Sayed Ul Alam Shibly2, SM Bakhtiar Ul Islam1, Jinath Sultana Jime1, Nayeema Bulbul1, Mohammad Badrul Anam3, Khanjada Shahnewaj Bin Mannan4, Md. Asaduzzaman Shishir5
The significance of microbe-induced angiogenesis and anti-angiogenesis lies in their pivotal roles in the pathogenesis and treatment of infectious diseases.
Abstract | Full Text |PDF (635 KB) | Open Access Article
Platelet Implication in Atherosclerosis Pathogenesis
Anastasia V. Poznyak 1*, Varvara A. Orekhova 1, Vasily N. Sukhorukov 1, Alexandra A. Melnichenko 2, Elizaveta M. Pleshko 2, Alexander N. Orekhov 1
Platelets' vital role in health, thrombosis, atherosclerosis; therapy's ongoing clarification.
Abstract | Full Text |PDF (541 KB) | Open Access Article
The peer-reviewed and edited version of record published online before inclusion in an issue
These articles have been peer reviewed and accepted for publication. They are still in production and have not been edited, so may differ from the final published form.
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Advanced Dissolution Testing for Novel Drug Formulations: Challenges, Emerging Methods, and Regulatory Perspectives
This study enhances drug release evaluation and improves therapeutic outcomes using advanced dissolution testing techniques.
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Analysis of Potential Biomarkers in Hypertension
Biomarker-driven hypertension diagnostics enhance early detection, predict complications, and support precision medicine strategies to reduce global cardiovascular disease burden.
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Predicting Habitat Suitability and Climate Change Impact on Medicinal plant Dalbergia latifolia and Dillenia pentagyna Using Ecological Niche Modelling
This study models current and future habitats, highlighting climate-driven distribution shifts and guiding conservation strategies for two economically valuable medicinal plants.
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A Comparative Analysis of Bioavailability and Stability of Anti-Diabetic Drugs in Conventional vs. Nanoparticle-Based Formulations – A Review
The study underscores nanoparticles' potential to improve stability, bioavailability, and therapeutic efficacy of anti-diabetic drugs versus conventional formulations.
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Effects of Physical Activity as A Treatment For Depression in the Elderly
Identifying effective physical activities for elderly depression supports holistic, low-cost, evidence-based interventions that enhance mental health and healthy aging.
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Strategic Impurity Control in Next-Generation Pharmaceuticals: Analytical Technologies, Toxicological Assessment, and Regulatory Integration
Effective impurity control safeguards patient safety while accelerating pharmaceutical innovation and regulatory approval.
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Collaborative Governance in Combating Illegal Cosmetics: A Study of Multi-Stakeholder Dynamics in South Sulawesi, Indonesia
This study evaluates collaborative governance in South Sulawesi to address illegal cosmetics, enhancing public health, regulatory compliance, and stakeholder coordination.
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Smart Nutrition and Active Living in Hypertension Management: Assessing Lifestyle Behaviors, Barriers, and the Role of Digital Health Tools
This study is significant as it highlights the effectiveness of smart nutrition and active living in managing hypertension, promoting sustainable, non-pharmacological interventions for better cardiovascular health.
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High Viral Load is a Risk Factor for Hepatocellular Carcinoma: Clinical and Laboratory Insights from a Cross-Sectional Study
High viral load in HCC patients correlates with worsened liver function, systemic complications, and increased mortality, underscoring the need for early intervention.
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Cardiovascular Complications in Patients with Hepatocellular Carcinoma
The study seeks to develop an HCC risk profile framework for clinicians to identify patients who may be at risk.
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The Importance of Autoimmunity and Chronic Inflammation in the Development of Atherosclerosis: New Treatment Strategies
Understanding immune mechanisms in atherosclerosis enables development of targeted anti-inflammatory therapies, improving cardiovascular outcomes and plaque stabilization strategies.
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Multidisciplinary Challenges in Managing a Ruptured Ascending Aortic Aneurysm with Concurrent Pulmonary Pathology: A Case Report
This case highlights the challenges of managing ruptured aortic aneurysms with comorbidities, emphasizing multidisciplinary care and TEVAR’s limitations in complex cases.
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The Evolving Role of Hospital and Community Pharmacist in Post-COVID-19 Healthcare Delivery in Bangladesh: A Survey-Based Analysis
This study highlights post-pandemic roles of Bangladeshi pharmacists, emphasizing their evolving contributions to healthcare access, management, and therapeutic decision-making.
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AI-driven Innovations in Cancer Research and Personalized Healthcare
This study demonstrated the potential of AI to revolutionize cancer care through improved diagnostics, personalized treatment, and ethical implementation.
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Synthesis, Characterization, and Antioxidant Potential of Nickel (II) Phthalocyanine for Industrial and Biomedical Applications
This study determined Nickel (II) phthalocyanine's antioxidant efficacy, structural characterization, and versatile applications in industry and therapeutic advancements.
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Bacteriological Profile of Bacteremia and Antibiotic Resistance Patterns of the Isolated Pathogens
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Antidiabetic and Toxicological Evaluation of Ostodes Pauciflora merr. Seed (kop nut) Oil, A Potential Functional Food Alternative
This study evaluates Ostodes pauciflora Merr. seed oil for antidiabetic properties, providing insights into its potential as a functional food alternative.
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An Insight into the Role of Artificial Intelligence in the Early Diagnosis of Alzheimer’s Disease
AI improves diagnosis, treatment planning, and patient outcomes by enabling early, accurate Alzheimer's disease identification using sophisticated data analysis.
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Cardiometabolic Impact of Vitamin D Deficiency as a Determinant of Coronary Artery Disease: A Review
The results demonstrate a strong link between vitamin D deficiency and an increased risk of coronary heart disease in adults.
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Potential Therapeutic Targets Associated with the Autoimmune Response in Crohn's Disease
This review elucidates autoimmune mechanisms in Crohn’s disease, highlighting emerging molecular targets to advance precision immunotherapy and improve patient outcomes.
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Deep Mapping of Neuro-phenotypes Using AI-Enhanced MRI: A Contrast-Based Multiplanar Analysis
AI-driven contrast mapping enhances voxel-level T2-MRI brain analysis, revealing phenotypic variations crucial for early diagnosis and neurodevelopmental profiling
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Revolutionizing Healthcare: The Role of Artificial Intelligence in Drug Discovery and Delivery
This study shows how AI can change the way drugs are made and delivered, making healthcare faster, more personalized, and cheaper.
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TGF-β1 as a Molecular Target and Vitamin D Interaction in Diabetic Nephropathy: A Bio-clinical Correlation Study
Clarifies the potential role of vitamin D and kidney dysfunction in diabetic nephropathy through clinical and molecular analysis.
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Integrating Molecular Modeling and Kinetic Insights to Decipher Structure–Activity Relationship Trends in Small-Molecule Inhibitors of α-Glycosidases
This study clarifies structural features driving potent α-glycosidase inhibition, enabling rational design of selective therapeutics through integrated computational–experimental mechanistic insights.
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Multichemical Endocrine Disruption of Thyroid and Sex Hormone Signaling Drives Early-Life Neurodevelopmental Impairments
This study highlights how prenatal endocrine disruptor exposure impairs neurodevelopment, emphasizing mixture effects, biological mechanisms, and urgent regulatory intervention needs.