The Impact of Cardiovascular Complications on Mortality and Public Health in Patients with Hepatocellular Carcinoma: A Multicenter Cohort Study

Hasnat; Azizur; Md.

doi:10.25163/health.3110225

Epidemiology and public health

RESEARCH ARTICLE (Open Access)

Previous Contents Vol 3 (1)

The Impact of Cardiovascular Complications on Mortality and Public Health in Patients with Hepatocellular Carcinoma: A Multicenter Cohort Study

Hasnat Karim¹*, Azizur Rahman², Md. Fatin¹

+ Author Affiliations

Clinical Epidemiology & Public Health 3 (1) 1-9 https://doi.org/10.25163/health.3110225

Submitted: 07 April 2025 Revised: 08 June 2025 Published: 10 June 2025

Abstract

Background: Hepatocellular carcinoma (HCC) is unmoving one of the deadliest cancers. It's single among malignancies outstanding to its cumulative occurrence. The value of overall survival is impacted by multiple factors such as stage and presence of metastatic disease, but there is a considerable focus on treatment-related survival outcomes. Cardiovascular morbidity in advanced HCC patients is, however, one of the least researched problems regarding healthcare resource utilization and cost. Methods: We showed a reflective unit study, which analyzed the data of 235 HCC affected role crossways three tertiary care hospitals. The related details were collected through electrical health records and comprised age, gender, clinical past, oncologic history, and comorbid cardiovascular diseases. Important cardiovascular actions of interest included congestive heart failure, arrhythmias, myocardial infarction, stroke, and existence. To perform results analysis, we advanced multivariable COX proportional dangers replicas for each result to estimate the danger of opposing cardiovascular proceedings. Results: Ensuing a HCC diagnosis, 28.5% of patients had oncological cardiovascular complications, the most public being: heart failure (34.3%), arrhythmias (31.3%), myocardial infarction (22.4%), and stroke (11.9%). Identified independent risk issues were: hypertension (HR 2.12; p<0.001), diabetes (HR 1.76; p=0.006), and extra advanced growth phase locally (HR 2.49; p<0.001). Those with cardiovascular proceedings experienced considerably lower survival compared to patients without (9.5 months versus 17.8 months <0.001). Conclusion: cardiovascular problems are prevalent and deteriorate survival prognosis in HCC patients. There is need for optimal cardio-oncology intercessions to improve outcome and healthcare spending efficiency in this high-risk population.

Keywords: Hepatocellular carcinoma, Cardiovascular disease, Survival analysis, public health, Cardio-oncology, Risk factor

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