Journal of Primeasia
Integrative Disciplinary Research | Online ISSN 3064-9870
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RESEARCH ARTICLE   (Open Access)
Contents Vol 6 (1)

Observational Study on the Clinical Manifestations and Feature of Dengue Fever

Kaniz Fatima Bari1, Md Tahsin Salam2, Mashsharat Maliha3, Bikom Chandra Singha4, A.K.M. Farjaul Islam5, Nakib Kamran Oni6, Sabbir Hossain7, Md Sefaut Ullah8, Meharajul Islam8, Tufael9*

+ Author Affiliations

Journal of Primeasia 6 (1) 1-8 https://doi.org/10.25163/primeasia.6110203

Submitted: 17 February 2025 Revised: 02 April 2025  Published: 06 April 2025 

Abstract

Background: Dengue Fever has continued to be one of the major health problems in Bangladesh, with changes in clinical features and epidemiological patterns. Recent outbreaks are marked with some striking changes in the manifestations of the disease, as compared to the past trends. Methods: This was a hospital based cross-sectional study comprising 590 laboratory confirmed cases of dengue from a tertiary care hospital in Dhaka. Diagnosis was made using NS1 antigen with a qualitative IgM antibody test. Demographic and clinical data, including history and examination, along with complete blood counts, liver function tests, and serology were done. Statistical analysis explains the trend of dengue. Results: The study showed the patient population was with a mean age of 42.5 (±15.2) years which means they were more on the older side and there was a notable preponderance of females (57.6%). The study revealed that thrombocytopenia was detected in 33.9%, which represented a significant reduction from previous outbreaks (66.1%). It was possible because there was important liver involvement and most of the patients had their ALT (95.6 U/L) and AST (81.1 U/L) levels elevated. There was strong association with HS dysfunction (p < 0.01) and poor overall NS1 antigenemia. Unlike previous outbreaks, the hemorrhagic symptoms were less frequent, while gastrointestinal symptoms remained notable. Conclusion: In Bangladesh, dengue fever is manifesting more liver symptoms and minimal bleeding signs. This suggests the need for new clinical guidelines emphasizing manipulation of liver function evaluation, active measures, and specific dengue serotype studies over time.

Keywords: Dengue fever, Bangladesh, thrombocytopenia, hepatic dysfunction, NS1 antigen, clinical trends

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