The Public Health Burden of Chronic Kidney Disease-Associated Hepatocellular Carcinoma
Rathashri Mallik1, Birupaksha Biswas2, Nadia Islam3, Md. Musfiqur Rahman4, Esrat Jahan Elora4, Md. Abul Hossain5, Md Mahedi Hasan Shabuj6, Asika Ayrin Naher7
Clinical Epidemiology & Public Health 3(1) 1-9 https://doi.org/10.25163/health.3110236
Submitted: 12 March 2025 Revised: 16 May 2025 Published: 18 May 2025
Abstract
Background: Hepatocellular carcinoma (HCC) ranks additional as the deadliest cancer, and around newly available literature proposes that the existence of chronic kidney illness may worsen the difficulty of important indicators like alpha-fetoprotein (AFP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and even platelet total. Methods: We confirmed a reflective cross-sectional study in three tertiary care centers which consisted of 255 patients with chronic liver bug (CLD) and had different degrees of renal meaning - normal, mild CKD, and simple CKD groups. Creatinine levels, eGFR, AFP, ALT, AST, and palates levels were gained and analyzed using ANOVA, correlation, and multivariate regression models. Results: There was a notable positive relationship between serum creatinine and AFP (r=0.62, p<0.001), whereby the most severely affected CKD patients had serum creatinine levels that were at least four-fold greater than those with normal renal functioning on AFP. With advancing CKD, ALT and AST levels gradually elevated while platelet counts markedly declined. Multivariate regression analysis showed that creatinine level independently predicted elevated AFP with the strongest relation amongst all age factors and liver damage proxies. Conclusion: The effects of chronic kidney disease (CKD) on hepatocellular carcinoma (HCC) biomarkers equal modifications cross with the well-known benchmarks, cumulative the indicative difficulty. Considering the rising global prevalence of CKD and liver disease, it leftovers important to evaluate renal function as part of the HCC surveillance system to facilitate earlier diagnosis and enhance management.
Keywords: Chronic Kidney Disease (CKD), Hepatocellular Carcinoma (HCC), Biomarkers, Liver Health, Public Health.
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