Potential Role of Helicobacter pylori Infection in Hepatocellular Carcinoma: A Clinical and Laboratory-Based Study

Moazzam Hossian ¹, Md. Mahmudul Hasan², Afrin Sultana ³, Shib Shankar Das ⁴, Pravas Paul⁵, Md Shamsuzzaman⁶, Md. Moshiur Rahman⁷, Md. Khaja Mohi Uddin⁸, Md. Abu Sayem ⁹, Md Samiul Bashir ^10*

The study is to determine the pervasiveness of H. pylori infection among patients with liver illness of HCC.

Abstract

Background: Helicobacter pylori (H. pylori) infection has been a pertinent global health concern with possible extra pulmonary related problems including liver concerns. This research required to determine the prevalence of H. pylori infections and its relationship with liver fibrosis and cirrhosis among patients attending the hospital while accounting a range of relevant demographics and clinical factors. Methodology: The total population sample in this study was 215, enrolled as participants for a cross-sectional observational study. Evaluation of H. pylori was conducted through serological and Chemiluminescence Immunoassay (CLIA) techniques. Other parameters that needed to be noted included demographic information, co-existing health disorders, lifestyle habits such as smoking or drinking alcohol, and biochemical indicators of liver health like ALT, AST, ALP, bilirubin, albumin etc. For comparative analysis between the populations, frequency distribution was done and later a comparative assessment through P-value relational definitional assessment for significant associations was computed. Results: The respondents were 51.6% women, and mostly in the 26-45 age bracket. H. Pylori contamination was revealed in 67.5% of the cases with 43.26% positive by Chemiluminescence Immunoassay (CLIA) and 24.19% by serology. Considerable associations were noted with H. Pylori for infection and elevated hepatic transaminases ALT, AST and ALP, and increased bilirubin levels (p < 0.05). Conclusion: It does appear from these results that H. Pylori infection has a considerable association with liver fibrosis or cirrhosis, demonstrating a need to control H. Pylori infection among patients with chronic liver disease or those who are prone to this disease.

Keywords: Helicobacter pylori, Hepatocellular carcinoma, Liver fibrosis, Cirrhosis, Liver function.

References